I'm looking for...
close

Did you know that your Internet Explorer is out of date?

To get the best possible experience using our website we recommend that you upgrade to a newer version or download another web browser.
A list of the most popular web browsers can be found below. Just click on the icons to get to the download page.

crome
Google Chrome		 IE
Internet Explorer		 firefox
Mozilla Firefox		 opera
Opera

Your browser will need to close to complete the installation and you will need to manually reload the site when finished
Hot Science Jobs
Senior QC Associate
Dublin
Senior QA Associate (shift)
Dublin
Quality Engineer
Galway
R&D Manager
Connaught
Biomedical Engineer
Dublin
R&D Manager
Connaught
Operations Engineer
Galway
Maintenance & Reliability Technician
Limerick
Principal R&D Engineer
Galway
R&D Manager
Galway
Supply Chain Project Manager (hybrid)
Dublin
R&D Manager
Athlone
Shift Technician (Injection Moulding)
Kildare
R&D Director
Galway
Senior R&D Manager - Lifecycle Manag
Galway
R&D Engineer
Galway
Senior R&D Engineer
Galway
Senior R&D Manager
Athlone
Design Assurance Engineer
Galway
Senior Quality Engineer
Dublin
Senior R&D Engineer
Dublin
QC Micro Analyst (4 cycle shift)
Cork
R&D Manager
Galway
Software Design Assurance Engineer
Dublin
Senior R&D Engineer
Galway
Senior Contract Development & Manufa
Dublin
Quality Engineer
Athlone
R&D Manager
Athlone
Process Development Engineer
Galway
Project Manager
Kildare
Principal Quality Engineer
Galway
Design Assurance Engineer
Galway
Senior Quality Engineer
Leitrim
CTO
Galway
Project Engineer
Roscommon
Project Engineer
Cork
Senior Quality Engineer
Galway
Quality Engineer
Galway
R&D Manager
Galway
Engineering Support Specialist
Louth
Project Manager
Kildare
Senior Maintenance Technician
Kilkenny
Senior Quality Engineer
Leitrim
Quality Assurance Specialist (shift)
Carlow
Senior Quality Engineer
Dublin
Validation Engineer
Carlow
Project Manager - R&D
Galway
Quality Specialist
Clare
Senior Quality Engineer
Dublin
Validation & Verification Engineer
Dublin
Senior Quality Assurance Specialist (hyb
Dublin
Quality Assurance Specialist (Logistics)
Dublin
Senior Process Engineer - DP or DS
Dublin
Senior Quality Engineer
Galway
Product Development Engineer
Galway
Senior Regulatory Affairs Specialist
Athlone
R&D Manager
Connaught
Regulatory Affairs Maanger
Galway
Director of Regulatory Affairs
Galway
Maintenance & Reliability Technician
Limerick
Senior Electronics Engineer
Dublin
Senior Product Development Engineer
Galway
Injection Moulding Engineer
Athlone
Senior R&D Manager
Athlone
Continuous Improvement Coach
Limerick
Principal Device Engineer
Dublin
QA Engineer
Leitrim
Business Development Manager (Hospitals)
Cork
Purchasing & Planning Manager
Wexford
QC Bioanalytical Sciences - Senior Assoc
Dublin
Quality Engineer
Galway
Marketing Manager
Galway
Continuous Improvement Coach
Limerick
Quality Specialist
Tipperary
Project Manager
Galway
Quality Technician
Dublin
Equipment Engineer (Syringe filling)
Dublin
Warehouse Operator
Meath
R&D Lifecycle Manager
Connaught
Design Assurance Program Manager
Galway
Senior QC Microbiology
Dublin
Senior R&D Engineer
Galway
Bioprocess Associate
Louth
R&D Engineer
Galway
R&D Engineer
Galway
Director of Regulatory Affairs
Galway
Product Development Engineer
Galway
R&D Director
Galway
R&D Engineer
Galway
Product Development Engineer II
Athlone
Senior Manufacting Engineer
Republic of Ireland
Analytical Chemist
Tipperary
CTO
Dublin
Principal R&D Engineer
Galway
Laboratory Systems Specialist
Meath
Senior Design Engineer
Dublin
Senior Process Development Engineer
Galway
Quality Assurance Senior Specialist
Louth
Documentation Specialist
Louth
Product Specialist (Critical Care &
Dublin
Principal R&D Engineer
Galway
Process Engineer
Leitrim
Purchasing & Planning Manager
Wexford
CQV Engineer
Dublin
Product Development Engineer II
Athlone
Business Manager (Critical Care & Me
Dublin
Documentation Specialist
Louth
Senior R&D Engineer
Dublin
Manufacturing Technician
Galway
Product Development Engineer
Dublin
Product Specialist (Endoscopy)
Dublin
Senior Quality Engineer
Leitrim
Senior Mechanical Engineer
Dublin
Industrial Designer
Galway
Senior R&D Manager - Lifecycle Manag
Galway
Senior Design Assurance Engineer
Galway
Senior Equipment Design Engineer
Dublin
Senior Project Engineer
Cavan
Senior Design Assurance Engineer
Galway
Senior Product Development Engineer
Galway
Quality Engineer
Athlone
Senior R&D Engineer
Clare
QC Instrumentation Specialist
Dublin
Calibration Technician
Republic of Ireland
Quality Engineer
Athlone
(Senior) Manufacturing Engineers - Globa
Limerick
Senior Design Assurance Engineer
Galway
Reg Affairs Specialist
Connaught
R&D Manager
Dublin
Manufacturing Technician
Clare
Quality Assurance Specialist (hybrid)
Dublin
Quality Systems Manager
Dublin
Principal R&D Engineer
Galway
Process Chemist
Limerick
Sterilisation Manager
Tipperary
Senior Regulatory Affairs Specialist
Clare
Quality Engineer
Galway
Quality Assurance Team Lead
Cork
Quality Technician
Dublin
R&D Engineer
Clare
Senior Principal Design and Development
Galway
Senior Validation Engineer - HVAC
Dublin
R&D Engineer
Galway
Senior Quality Systems Engineer
Galway
R&D Engineer
Dublin
Business Development Manager
Republic of Ireland
Quality Manager - Medical Devices
Limerick City
Project Manager - New Product Introducti
Dublin
Director of R&D
Limerick
Project Manager (hybrid)
Dublin
Commercial Attribute Science Snr Associa
Dublin
Director of R&D
Clare
Senior Research and Development Engineer
Galway
Quality Specialist
Clare
Technical Life Cycle & Engineering M
Galway
R&D Engineer
Dublin
Staff R&D Engineer
Limerick
Senior Associate QC (QC Sample Managemen
Dublin
Product Development Engineer II
Athlone
Director of Quality Engineering
Limerick
Quality Assurance Associate
Cork
R&D Director
Galway
Microbiology Manager
Dublin
Quality Engineer - Supplier
Galway
R&D Manager
Galway
Senior Regulatory Affairs Specialist
Athlone
Clinical Trial Manager
Republic of Ireland
Injection Moulding Engineer
Leitrim
Senior QC Technical Services - Equipment
Dublin
Injection Molding Engineer
North Leinster
Senior Electrical Engineer
Galway
Key Account Manager - Retail UK National
South East
Responsible Person (RP)
Republic of Ireland
Senior Quality Engineer
Dublin
Validation Engineer
Athlone
Injection Moulding Engineer
Athlone
Quality Assurance Specialist/Manager
Dublin
Advanced Technologies Manager
Galway
Senior Manufacturing Engineer
Galway City
Sr Project Manager - Syringe Fill Engine
Dublin
R&D Engineer
Galway
Quality Manager
Galway
Quality Engineer
Galway
Senior Quality Engineer
Dublin
Senior Electronic Engineer
Dublin
Electrical Technician
Limerick
Product Development Engineer
Galway
Senior Regulatory Affairs Specialist
Athlone
Quality Assurance Specialist (shift)
Carlow
Principal R&D Engineer
Dublin
Senior QC Micro Analyst
Cork
Staff Systems Engineer
Limerick
Senior Quality Systems Engineer
Galway
R&D Manager
Galway
Principal Engineer
Dublin
Accreditation Manager
Republic of Ireland
Senior R&D Engineer
Galway
Senior Electronic Engineer - Regulated M
Galway
QA Manager
Canada
R&D Manager
Connaught
Principal R&D Engineer
Dublin
Senior Maintenance Technician
Kilkenny
Senior Equipment Design Engineer
Dublin
R&D Engineer
Galway
Principal Design and Development Enginee
Galway
Senior Associate Quality Control (Shift)
Dublin
Quality Assurance Manager
Dublin
Consultant




Search Results for Downstream Process
Job Title. Location Salary Actions

Advanced Technologies Manager

Job title: Advanced Technologies R&D Manager Location: Ballybrit, Galway Benefits: Competitive salary, 13% yearly bonus, share options, pension and Healthcare. Company: My client is an emerging leader in Neurovascular care in the Medical Device industry. Located in a European hub for the Medical Device industry my client works closely with physicians from around the world to develop devices used in the endovascular treatment of strokes. Role: As an Advanced Technologies R&D Manager you will be responsible for providing t...

Location: Galway, Galway City,
Advanced Technologies Manager 		Galway Not Disclosed
Subscribe RSS feed for this search

Downstream Process Career Profile

Downstream Processing Engineer

Downstream processing the isolation and purification of the biotech product, which has been producted in the fermentation (upstream stage). As the desired product is usually secreted into the medium, the first step is normally filtration or centrifugation. Liquid chromatography and / or membrane filtration is then used to separate the desired protein product from the other proteins present in the mixture, in order to concentrate the desired biopharmaceutical product.


Key Responsibilities of the Downstream Processing Engineer

  • Participate in facility and process design of a multi-product biopharmaceutical manufacturing platform.
  • Play a role in commissioning and start-up of the biotech facility.
  • Play a role in developing and predicting processing strategies and throughputs for the various products for the site biotech business.
  • Provide day-to-day bioprocess engineering support to downstream manufacturing operations.
  • Initiate facility and equipment upgrades to improve plant productivity and throughput.
  • Facilitate the introduction of new products with associated new equipment and ensure the bioprocessing at the site stays current with emerging processing and equipment trends.
Required Qualifications & Experience
  • A degree-level or higher qualification in Biochemical/Chemical Engineering or a related discipline.
  • Knowledge of the downstream biopharmaceutical unit operations involved with bioreactor design and control, Sterilisation in Place (SIP) / Cleaning in Place (CIP), filtration etc.
  • Experience in either design or commissioning of a mammalian cell-based biopharmaceutical manufacturing plant.
  • Operations experience in purification or related bioprocess manufacturing experience in an established biotech production operation.