I'm looking for...
close

Did you know that your Internet Explorer is out of date?

To get the best possible experience using our website we recommend that you upgrade to a newer version or download another web browser.
A list of the most popular web browsers can be found below. Just click on the icons to get to the download page.

crome
Google Chrome		 IE
Internet Explorer		 firefox
Mozilla Firefox		 opera
Opera

Your browser will need to close to complete the installation and you will need to manually reload the site when finished
Hot Science Jobs
R&D Senior Program Manager
Galway
Quality Assurance Specialist
Waterford
Senior Operations Engineer
Galway
Equipment Engineer Intermediate
Dublin
R&D Technician II
Galway
Design Assurance Engineer
Galway
Product Development Manager
Galway
CQV Engineer
Roscommon
Senior Clinical Engagement Project Manag
Dublin
Business Manager (Woundcare, Orthopaedic
Dublin
Quality Engineer
Athlone
Project Engineer
Clare
Senior Maintenance Technician
Kilkenny
Clinical Trial Protocol Specialist
Galway
Principal Design and Development Enginee
Galway
Senior Clinical Data Analyst
Dublin
R&D Engineer
Dublin
R&D Engineer
Galway
Project Manager - New Product Introducti
Dublin
Sales Specialist (Life Sciences)
Dublin
Senior Electronic Engineer
Dublin
Senior Equipment Design Engineer
Dublin
Product Specialist (Critical Care &
Dublin
Principal Engineer
Dublin
Senior Engineering Manager
Galway
Senior Quality Engineer
Leitrim
Quality Manager
Galway
Strategic Automation Lead
Waterford
Product Development Engineer
Dublin
Product Development Engineer II
Athlone
Principal Software Engineer
Athlone
Senior R&D Engineer
Galway
Software Design Assurance Engineer
Dublin
R&D Technician
Galway
Senior Quality Engineer
Dublin
Senior R&D Manager - Lifecycle Manag
Galway
Senior Quality Engineer
Galway
Clinical Advisor - Wound care (Part-time
Dublin
Senior Regulatory Affairs Specialist
Athlone
R&D Manager
Connaught
Senior Operational Readiness Associate
Dublin
Senior Design Engineer
Dublin
Senior Quality Systems Engineer
Galway
Project Engineer
Cork
Instrumentation Engineer
Meath
Senior Maintenance Technician
Kilkenny
Clinical Trial Protocol Specialist
Galway
Senior Quality Engineer
Dublin
Senior R&D Engineer
Galway
Principal R&D Engineer
Galway
Senior Regulatory Affairs Specialist
Athlone
Scientific Officer- Virology
Dublin
Product Development Engineer
Galway
Biomedical Engineer
Dublin
R&D Manager
Galway
Advanced Technologies Manager
Galway
Senior R&D Engineer-New Product Deve
Westmeath
Senior Design Assurance Engineer
Galway
Business Development Manager (Pharmacy O
Dublin
Supplier Quality Engineer
Galway
Production Manager
Dublin
Quality Systems Manager
Dublin
R&D Engineer
Galway
Injection Molding Engineer
Mayo
Principal R&D Engineer
Galway
Senior R&D Manager - Lifecycle Manag
Galway
Principal R&D Engineer
Galway
Senior Regulatroy Affairs Specialsit
Galway
Manufacturing Technician
Clare
Product Development Technician II
Galway
Quality Assurance Senior Specialist
Louth
Principal Process Equipment Engineer
Dublin South
Senior Regulatory Affairs Specialist
Dublin
Senior Research & Development Engine
Limerick
Principal R&D Engineer
Dublin
R&D Engineer
Galway
Quality Control (QC) Technician
Kildare
Quality Engineer
Athlone
Quality Assurance Specialist (shift)
Carlow
R&D Engineer
Dublin
Product Development Engineer II
Athlone
Project Manager
Galway
Head of Digital & Technology
Dublin
Manufacturing Specialist (Investigation
Dublin
Quality Engineer
Galway
Application Software Engineer
Galway
Quality Manager
Galway
Advanced Technologies R&D Manager
Clare
Senior QC Microbiology
Dublin
EHSS Specialist
Athlone
R&D Program Manager
Dublin
Senior Product Development Engineer
Galway
Validation Engineer
Athlone
R&D Manager
Dublin
R&D Director
Galway
Senior Engineering Manager
Galway
Responsible Person (RP)
Republic of Ireland
Senior Design Assurance Engineer
Galway
Senior R&D Engineer
Galway
Senior QA Associate (shift)
Dublin
Quality Technician
Dublin
Senior Technology Transfer Specialist
Dublin
Senior Engineering Manager
Galway
Calibration Technician
Republic of Ireland
Senior Clinical Data Analyst
Dublin
R&D Director
Galway
Senior R&D Manager
Athlone
Senior Maintenance Technician
Kilkenny
Senior Manufacting Engineer
Republic of Ireland
Validation Engineer
Dublin
Quality Technician
Dublin
Design Assurance Engineer
Galway
R&D Manager
Athlone
Senior Quality Assurance Specialist (hyb
Dublin
Documentation Specialist
Louth
Staff R&D Engineer
Limerick
Lead Mechanical Design Engineer
Limerick
QC Microbiology Technician
Kildare
Senior Supplier Engagement Manager
Dublin
Quality Technician
Galway
Senior Supply Chain Project Manager
Dublin
Senior Maintenance Technician
Roscommon
Regulatory Affairs Maanger
Galway
R&D Engineer
Galway
QA Engineer
Leitrim
Website Audit Specialist
Dublin
Quality and Regulatory Affairs Manager
Dublin
Biomedical Engineer
Dublin
Laboratory Systems Specialist
Meath
R&D Manager
Galway
Senior Regulatory Affairs
Galway
Quality Engineer - Supplier
Galway
EHS Specialist II
Limerick
Design Assurance Manager
Galway
R&D Manager
Connaught
Project Manager (hybrid)
Dublin
R&D Engineer
Galway
Senior Design Engineer
Dublin
Senior Equipment Design Engineer
Dublin
LIMS Specialist
Tipperary
Quality Specialist
Clare
Inside Sales Support & Sourcing Spec
Dublin
Senior Project Engineer - R&D
Galway
Quality Manager - NPI
Dublin
Senior Design Assurance Engineer
Galway
Quality Manager
Galway
QA Manager
Canada
Regulatory Affairs Manager- Remote
Republic of Ireland
Senior R&D Engineer
Galway
Quality Manager - Medical Devices
Limerick City
R&D Director
Galway
Quality Technician
Dublin
R&D Technician II
Galway
Project Manager
Kildare
Bioinformatician
Dublin
Senior Process Engineer
Dublin
Project Engineer
Roscommon
Quality Assurance Specialist/Manager
Dublin
Black Utilities Engineer
Westmeath
Quality Assurance Specialist (hybrid)
Dublin
Principal Quality Engineer
Galway
Director of R&D
Limerick
CTO
Galway
R&D Manager
Galway
Laboratory Technician (Microbiology &
Dublin
Senior Quality Assurance Associate
Dublin
Principal Engineer
Dublin
Sr Electrical Engineer
Galway
Principal R&D Engineer
Galway
Senior Regulatory Affairs Specialist
Athlone
Senior Quality Assurance Associate
Dublin
Senior Principal Design and Development
Galway
QC Microbiology Analyst
Dublin
Senior Sterile Drug Product MSAT Consult
Republic of Ireland
Documentation Specialist
Louth
Quality Manager
Galway
R&D Engineer
Galway
Clinical Sales Specialist (Histology)
Dublin
Principal Engineer
Dublin
Tech Transfer Lead
Dublin
Quality Assurance Specialist - Tech Tran
Dublin
Senior Product Development Engineer
Galway
Quality Specialist
Clare
Senior Regulatory Affairs Specialist
Athlone
Senior Quality Assurance Engineer
Galway
Bid Response Strategy Manager
Dublin
Senior Operations Engineer
Galway
Manufacturing Technician
Clare
Injection Moulding Engineer
Athlone
Senior QC Specialist
Dublin
EHS Specialist II
Limerick
R&D Engineer
Galway
Lead MSAT Validation Consultant
Republic of Ireland
Technical Life Cycle & Engineering M
Galway
Senior QC Microbiology
Dublin
Senior Manufacturing Engineer
Galway City
Senior QC Analyst
Republic of Ireland
R&D Engineer
Galway
Quality Assurance Associate
Cork
Senior Quality Engineer
Dublin
Proposal Manager
Dublin
Pharmacovigilance Manager (Remote)
Republic of Ireland
R&D Engineer
Clare
Quality Control Analyst (Cell Culture)
Carlow
Business Development Manager (Hospitals)
Cork
Senior Design Assurance Engineer
Galway
Director of Regulatory Affairs
Galway
Project Manager
Kildare
Quality Manager
Dublin
Quality Assurance Team Lead
Cork
Senior Production Manager
Cork
EHSS Specialist (Construction & Comm
Athlone
R&D Engineer
Galway
Manufacturing Technician
Clare
R&D Manager
Galway
Senior Quality Engineer
Galway
R&D Manager
Connaught
Quality Manager
Galway
Quality Engineer
Galway
R&D Manager
Athlone
Quality Manager
Galway
Warehouse Operator
Dublin
Process Chemist
Limerick
Quality Specialist
Tipperary
Senior Project Engineer
Cork
Injection Moulding Engineer
Athlone
R&D Manager
Connaught
Senior Project Engineer
Cavan
Business Development Manager
Republic of Ireland
Senior Equipment Design Engineer
Dublin
Operations Manager
Galway
Quality Manager
Galway
Quality Engineer
Athlone
Senior Mechanical Engineer
Dublin
Quality Specialist
Clare
R&D Engineer
Galway
Senior Design Engineer
Dublin
Quality Engineer
Wexford
Quality Assurance Specialist (Hybrid)
Dublin
Product Development Manager
Galway
CTO
Dublin
Senior R&D Engineer
Dublin
A.I Specialist
Clare
Engineering Business Manager
Dublin
R&D Manager
Galway
Senior R&D Engineer
Clare
Consultant




Search Results for Downstream Process
Job Title. Location Salary Actions

Advanced Technologies Manager

Job title: Advanced Technologies R&D Manager Location: Ballybrit, Galway Benefits: Competitive salary, 13% yearly bonus, share options, pension and Healthcare. Company: My client is an emerging leader in Neurovascular care in the Medical Device industry. Located in a European hub for the Medical Device industry my client works closely with physicians from around the world to develop devices used in the endovascular treatment of strokes. Role: As an Advanced Technologies R&D Manager you will be responsible for providing t...

Location: Galway, Galway City,
Advanced Technologies Manager 		Galway Not Disclosed
Subscribe RSS feed for this search

Downstream Process Career Profile

Downstream Processing Engineer

Downstream processing the isolation and purification of the biotech product, which has been producted in the fermentation (upstream stage). As the desired product is usually secreted into the medium, the first step is normally filtration or centrifugation. Liquid chromatography and / or membrane filtration is then used to separate the desired protein product from the other proteins present in the mixture, in order to concentrate the desired biopharmaceutical product.


Key Responsibilities of the Downstream Processing Engineer

  • Participate in facility and process design of a multi-product biopharmaceutical manufacturing platform.
  • Play a role in commissioning and start-up of the biotech facility.
  • Play a role in developing and predicting processing strategies and throughputs for the various products for the site biotech business.
  • Provide day-to-day bioprocess engineering support to downstream manufacturing operations.
  • Initiate facility and equipment upgrades to improve plant productivity and throughput.
  • Facilitate the introduction of new products with associated new equipment and ensure the bioprocessing at the site stays current with emerging processing and equipment trends.
Required Qualifications & Experience
  • A degree-level or higher qualification in Biochemical/Chemical Engineering or a related discipline.
  • Knowledge of the downstream biopharmaceutical unit operations involved with bioreactor design and control, Sterilisation in Place (SIP) / Cleaning in Place (CIP), filtration etc.
  • Experience in either design or commissioning of a mammalian cell-based biopharmaceutical manufacturing plant.
  • Operations experience in purification or related bioprocess manufacturing experience in an established biotech production operation.